ASSOCIATIONS BETWEEN GLENOHUMERAL ROTATION STRENGTH AND SELECT KINETIC PARAMETERS DURING THE BASEBALL PITCH IN ADOLESCENT BASEBALL PITCHERS

The purpose of this study was to examine the associations between isometric glenohumeral rotation strength and select biomechanical parameters during the pitching motion in adolescent baseball pitchers. Glenohumeral (GH) rotation strength and pitching kinetic data were assessed in 28 (14.2 ±0.94 yrs; 66.5 ±11.7 kg; 175 ±10.8 cm) adolescent baseball pitchers. Spearman’s rank correlations were used to assess relationships between GH rotation strength and upper extremity torques during the pitching motion. Peak GH internal rotation torque during the pitch was negatively correlated with the ratio of throwing arm external rotation strength to non-throwing arm external rotation strength (r= -0.552, p \u3c 0.05). These results provide evidence for a potential mechanism behind the increased injury risk seen in pitchers who exhibit GH external rotation weakness

USAGE AND ACCEPTABIITY OF DATA NORMALIZATION IN BASEBALL PITCHING

To account for athletes of different sizes, kinetic values are commonly ‘normalized’ by dividing by mass and/or height. However, the creation of a ratio variable requires certain statistical assumptions to be met. The purpose of this study was to determine if elbow valgus torque predicted by pitching velocity is influenced by the normalization method using regression model comparison with normalized torque values. Both mass and mass*height normalization satisfied the correlation and zero intercept assumptions. Results did not agree between analysis methods that elbow valgus torque could be predicted with pitching velocity at the α = 0.05 level, indicating caution should be exercised before normalizing pitching kinetics data without confirming the assumptions for a ratio variable are met

Recruitment of p300/CBP in p53-Dependent Signal Pathways

AbstractThe products of the p53 and CBP/p300 genes have been individually implicated in control of cell growth and regulation of transcription. p53 is known to act as a positive and negative regulator of gene expression. Here we show that p53, in both wild-type and mutant conformation, forms a specific protein complex with p300. However, in its wild-type but not mutant conformation, p53 inhibits a promoter containing the DNA-binding sequences for the transcription factor AP1, in a p300-dependent manner. p300 stimulates the transcriptional activity of p53 on p53-regulated promoters, and it enhances the responsiveness to a physiological upstream modulator of p53 function, ionizing radiation. A dominant negative form of p300 prevents transcriptional activation by p53, and it counteracts p53-mediated G1 arrest and apoptosis. The data implicate p300 as an important component of p53-signaling, thus providing new insight into the mechanisms of cellular proliferation

Hemoperitoneum identified by focused assessment with sonography for trauma following cardiopulmonary resuscitation.

It is generally recognized that lives are saved by administering high-quality cardiopulmonary resuscitation (CPR) to patients in cardiac arrest. A focused assessment with sonography for trauma (FAST) examination is an effective and non-invasive method for detecting rare complications of CPR, such as hemorrhage from abdominal visceral injury. We report the case of a 56-year-old female suffering from intra-abdominal hemorrhage caused by a liver laceration following CPR. The hemoperitoneum was diagnosed by a FAST examination. Although severe complications of CPR are rare, they can be easily detected with the use of a FAST examination. A FAST examination should be considered as a post-resuscitation approach to assess for life-threatening complications in all patients following cardiopulmonary resuscitation

THE RELATIONSHIP BETWEEN TRUNK ENERGY FLOW AND COLLEGIATE SOFTBALL HITTING PERFORMANCE

The purpose of this study was to determine the relationship between trunk energy flow and performance (exit velocity) during collegiate softball hitting. Nineteen collegiate softball athletes (age: 19.6 ± 1.0yrs) performed three maximal effort swings off a pitching machine. Kinematic data were collected using an electromagnetic tracking system. A segmental power analysis was performed to quantify peak rates of trunk energy flow (proximal inflow (IF) and distal outflow (OF) on front and back sides). Regression analyses determined exit velocity was best predicted by peak rate of distal trunk energy OF on the front side. On average, the model showed exit velocity increased by .9 mph for every 100 W increase in distal trunk energy OF on the front side while holding body mass constant

Jefferson Teamwork Observation Guide (JTOG): A Pilot Project

The critical need for students to learn to be effective members of interprofessional teams in preparation for collaborative practice-ready care provision now and in the future has been well documented1. There are increasing opportunities for students to observe interprofessional events to assist them in doing so, but often their role is passive and the teams may not demonstrate the highest level of patient-centered care, minimizing the student learning